Result | mutation | Your testing shows that you have a pathogenic mutation (a disease-causing change in the gene, like a spelling mistake) or a variant that is likely pathogenic in the CHEK2 gene. Both of these results should be considered positive. |
Gene | CHEK2 | Everyone has two copies of the CHEK2 gene, which we randomly inherit from each of our parents. Mutations in one copy of the CHEK2 gene can increase the chance for you to develop certain types of cancer in your lifetime. |
Cancer Risks | Increased | You have an increased chance to develop female breast cancer (around twice as high as the average woman), colorectal cancer, and possibly other cancers such as male breast cancer, prostate, thyroid, ovarian, or kidney. |
Management Options | for women | Options for early detection and prevention for women depend on your family history of cancer and may include: breast exam, mammogram, breast MRI, and options for preventive surgery. Talk to your doctor about what options may be right for you. |
Management Options | for men & women | Options for early detection and prevention for both women and men depend on your family history of cancer and may include colonoscopies, comprehensive physical exams, or other screening options. Talk to your doctor about what options may be right for you. |
Risk Management | varies | Risk management decisions are very personal, and the best option depends on many factors. Screening typically begins earlier than the general population and is often more frequently performed. It is important to discuss these options with your doctor. |
Family Members | 50/50 chance | Your close relatives (like your parents, brothers, sisters, children) have a 50/50 random chance of inheriting the CHEK2 mutation that you carry, and other family members (like your aunts, uncles, cousins) may also inherit it. Your relatives can be tested for this same mutation. Depending on the family history, those who DO NOT have it may not have an increased chance (above the general population) to develop cancer. |
Next Steps | discuss | It is recommended that you share this information with family members so they can learn more and discuss this with their healthcare providers. |
Reach Out | resources |
|
Application symbol | Meaning | Mechanical Property | Details |
---|---|---|---|
S | Structural steel | Minimum Yield Strength | |
P | Steel for pressure lines and vessels | Minimum Yield Strength | |
L | Steel for pipe and tube | Minimum Yield Strength | |
E | Engineering steels | Minimum Yield Strength | |
B | Steel for reinforced concrete | Characteristic Yield Case | |
R | Steel for rail use | Minimum Yield Case | |
H | High Tensile Strength Flat products | Minimum Yield Case | If followed by T then the given mechanical property is minimum tensile strength |
D | Flat Products for Cold Forming | Followed by C, D or X and two numbers characterising steel | |
T | Tinmill Products | Nominal Yield Case | |
M | Electrical Steel | Number = 100 × specific loss in W/kg Number = 100 × nom thick in mm Letter for type of product (A, K, P or S[3]) |
Impact Resistance | Temperature | ||
---|---|---|---|
Impact code | Testing strength | Temperature code | Testing temperature |
J | 27 J | R | Room temperature |
K | 40 J | O | 0 °C |
L | 60 J | 2 | -20 °C |
3 | -30 °C | ||
4 | -40 °C | ||
5 | -50 °C | ||
6 | -60 °C |
Code | Condition |
---|---|
A | Annealed |
QT | Quenched and tempered |
N | Normalised |
SR | Stress relieved |
C | Cold worked |
U | Untreated |
Code | Maximum specific loss expressed for magnetic induction | Type of product |
---|---|---|
A | 1.5 T @50 Hz | non oriented |
D (formerly B) | ' | non-alloy semi-finished (not finally annealed) |
E | ' | alloy semi-finished (not finally annealed) |
K (=D+E) | ' | non-alloy and alloy electrical steel sheet/strip in the semi-processed state |
N | ' | for normal grain oriented products |
P | 1.7 T @50 Hz | high permeability grain oriented |
S | ' | conventional grain oriented |
Code | Type |
---|---|
Non-alloy steels | |
00 & 90 | Basic steels |
0x & 9x | Quality steels |
1x | Special steels |
Alloy steels | |
2x | Tool steels |
3x | Miscellaneous steels |
4x | Stainless and heat resistant steels |
5x – 8x | Structural, pressure vessel and engineering steels |
08 & 98 | Special physical properties |
09 & 99 | Other purpose steels |
EN steel number (Europe) | EN steel name (Europe) | ASTM grade (USA) | AISI/SAE grade (USA) | UNS (USA) | DIN (Germany) | BS (UK) | UNI (Italy) | JIS (Japan) |
---|---|---|---|---|---|---|---|---|
Carbon steels | ||||||||
1.1141 1.0401 1.0453 | C15D C18D | 1010 1018 | CK15 C15 C16.8 | 040A15 080M15 080A15 EN3B | C15 C16 1C15 | S12C S15 S15CK S15C | ||
1.0503 1.1191 1.1193 1.1194 | C45 | 1045 | C45 CK45 CF45 CQ45 | 060A47 080A46 080M46 | C45 1C45 C46 C43 | S45C S48C | ||
1.0726 1.0727 | 35S20 45S20 | 1140/1146 | 35S20 45S20 | 212M40 En8M | ||||
1.0715 1.0736 | 11SMn37 | 1215 | 9SMn28 9SMn36 | 230M07 En1A | CF9SMn28 CF9SMn36 | SUM 25 SUM 22 | ||
1.0718 1.0737 | 11SMnPb30 11SMnPb37 | 12L14 | 9SMnPb28 9SMnPb36 | 230M07 Leaded En1B Leaded | CF9SMnPb29 CF9SMnPb36 | SUM 22 SUM 23 SUM 24 | ||
Alloy steels | ||||||||
1.7218 | 4130 | 25CrMo4 GS-25CrMo4 | 708A30 CDS110 | 25CrMo4 (KB) 30CrMo4 | SCM 420 SCM 430 SCCrM1 | |||
1.7223 1.7225 1.7227 1.3563 | 42CrMo4 | 4140/4142 | 41CrMo4 42CrMo4 42CrMoS4 43CrMo4 | 708M40 708A42 709M40 En19 En19C | 41CrMo4 38CrMo4 (KB) G40 CrMo4 42CrMo4 | SCM 440 SCM 440H SNB 7 SCM 4M SCM 4 | ||
1.6582 1.6562 | 34CrNiMo6 | 4340 | 34CrNiMo6 40NiCrMo8-4 | 817M40 En24 | 35NiCrMo6 (KB) 40NiCrMo7 (KB) | SNCM 447 SNB24-1-5 | ||
1.6543 1.6523 | 20NiCrMo2-2 | 8620 | 21NiCrMo22 21NiCrMo2 | 805A20 805M20 | 20NiCrMo2 | SNCM 200 (H) | ||
1.5415 | 16Mo3 | A240 A/B/C | K12822 K12320 K12020 K11820 | 15Mo3 | 1503-243B 240 243 | 15Mo3 16Mo3 | STBA12 | |
Stainless steels | ||||||||
1.4310 | X10CrNi18-8 | 301 | S30100 | |||||
1.4318 | X2CrNiN18-7 | 301LN | ||||||
1.4305 | X8CrNiS18-9 | 303 | S30300 | X10CrNiS18-9 | 303S 31 En58M | X10CrNiS18-09 | SUS 303 | |
1.4301 | X2CrNi19-11 X2CrNi18-10 | 304 | S30400 | X5CrNi18-9 X5CrNi18-10 XCrNi19-9 | 304S 15 304S 16 304S 18 304S 25 En58E | X5CrNi18-10 | SUS 304 SUS 304-CSP | |
1.4306 | X2CrNi19-11 | 304L | S30403 | 304S 11 | SUS304L | |||
1.4311 | X2CrNiN18-10 | 304LN | S30453 | |||||
1.4948[citation needed] | X6CrNi18-11 | 304H | S30409 | |||||
1.4303[citation needed] | X5CrNi18-12 | 305 | S30500 | |||||
1.4401 1.4436 | X5CrNiMo17-12-2 X5CrNiMo18-14-3 | 316 | S31600 | X5CrNiMo17 12 2 X5CrNiMo17 13 3 X5CrNiMo 19 11 X5CrNiMo 18 11 | 316S 29 316S 31 316S 33 En58J | X5CrNiMo17 12 X5CrNiMo17 13 X8CrNiMo17 13 | SUS 316 SUS316TP | |
1.4404 | X2CrNiMo17-12-2 | 316L | S31603 | 316S 11 | SUS316L | |||
1.4406 1.4429 | X2CrNiMoN17-12-2 X2CrNiMoN17-13-3 | 316LN | S31653 | |||||
1.4571 | 316Ti | S31635 | X6CrNiMoTi17-12 | 320S 33 | ||||
1.4438 | X2CrNiMo18-15-4 | 317L | S31703 | |||||
1.4541 | 321 | S32100 | X6CrNiTi18-10 | 321S 31 | SUS321 | |||
1.4848 | GX40CrNiSi25-20 | A351 HK40 | J94204 | SEW 595 GX40CrNiSi25-20 | 310C40 | SCH22 | ||
1.4859 | GX10NiCrSiNb32-20 | N08151 | GX10NiCrSiNb32-20 | |||||
1.4878,[citation needed] | X12CrNiTi18-9 X8CrNiTi18-10 | 321H | S32109 | |||||
1.4906 | X7CrNiNb18-10 | 347H | S34709 | |||||
1.4512[citation needed] | X6CrTi12 | 409 | S40900 | SUH409 | ||||
410 | S41000 | |||||||
1.4016 | 430 | S43000 | X6Cr17 | 430S 17 | SUS430 | |||
440A | S44002 | |||||||
1.4112[citation needed] | 440B | S44003 | ||||||
1.4125[citation needed] | 440C | S44004 | X105CrMo17 | SUS440C | ||||
1.4104 | 430F | S44020 | X14CrMoS17 | SUS430F | ||||
1.4057 | X17CrNi16-2 | 431 X[6] | S43100 | X16CrNi16 | 431S 29 | SUS431 | ||
1.5423 | 16Mo5 | A335 P1 | 4520 4419H 4419 | K11522 | 16Mo5 | STPA12 | ||
1.7715 | 14MoV6-3 | A335 P2 | K11547 | 14MoV6-3 | 660 | STPA20 | ||
1.7335 1.7338 | 13CrMo4-5 10CrMo5-5 | A335 P11 | K11597 | STPA23 | ||||
1.7375 1.7380 1.7383 | 10CrMo9-10 11CrMo9-10 12CrMo9-10 | A335 P22 | K21590 | 17175 10CrMo910 | STPA24 | |||
1.7362 1.7366 | X11CrMo5 X12CrMo5 12CrMo19-5 | A335 P5 | 501 502 | K41545 S50100 S50200 | STPA25 | |||
1.7386 | X11CrMo9-1 X12CrMo9-1 | A335 P9 | 503 | S50400 S50488 K90941 | STPA26 | |||
1.4903 | X10CrMoVNbN9-1 | A335 P91 | K91560 | X10CrMoVNbN9-1 | ||||
1.4905 1.4906 | X11CrMoWVNb9-1-1 X12CrMoWVNbN10-1-1 | A335 P92 | K92460 | X11CrMoWVNb9-1-1 X12CrMoWVNbN10-1-1 | ||||
1.4539 | X1NiCrMoCu25-20-5 | 904L | N08904 | |||||
1.4547 | X1CrNiMoCuN20-18-7 | S31254 | ||||||
1.4565 | NIT50 | S20910 | ||||||
NIT60 | S21800 | |||||||
Tool steels | ||||||||
1.2363 | X100CrMoV5 | A-2 | T30102[7] | X100CrMoV51 | BA 2 | X100CrMoV5-1 KU | SKD 12 | |
A-3 | T30103[8] | |||||||
A-4 | T30104[9] | |||||||
A-6 | T30106[10] | |||||||
A-7 | T30107[11] | |||||||
A-8 | T30108[12] | |||||||
A-9 | T30109[13] | |||||||
1.2365 | X32CrMoV3-3 32CrMoV12-28 | H10 | T20810 | X32CrMoV3-3 32CrMoV12-28 | SKD 7 | |||
1.2379 | X153CrMoV12 | D-2 | X153CrMoV12-1 | BD 2 | X155CrVMo12-1 | SKD 11 | ||
1.2510 | O-1 | 100MnCrW4 | Bo 1 | 95MnWCr-5 KU |
Steel Grade | Coupling | Tubular Body | |
---|---|---|---|
API Tubing and Casing | H40 | None | None or black band at the manufacturer's option |
J55 | all green. | one green band | |
K55 | all green | two green bands | |
N80-1 | all red | one red band | |
N80-Q | all red + one green band | one red band + one green band | |
L80-1 | all red + one brown band | one red band + one brown band | |
L80-9Cr | colorless + two yellow bands | one red band + one brown band + two yellow bands | |
L80-13Cr | colorless + one yellow band | one red band + one brown band + one yellow band | |
C90-1 | all purple | one purple band | |
T95-1 | all silver | one silver band | |
C110 | all white + two brown bands | one white band + two brown bands | |
P110 | all white | one white band | |
Q125 | all orange | one orange band |